Kidney Function

Estimated GFR — What Your Blood Test Result Means

ScanHealth Learn Kidney Function Estimated GFR

Your Kidney Filtration Score

eGFR estimates how many milliliters of blood your kidneys filter per minute. Think of it as a performance rating for your kidneys. A score above 90 means excellent filtration. Below 60 means chronic kidney disease. Below 15 means kidney failure.

What is Estimated GFR?

eGFR is calculated from creatinine (or cystatin C), age, and sex. It's the primary metric for diagnosing and staging chronic kidney disease (CKD): Stage 1 (>90), Stage 2 (60-89), Stage 3 (30-59), Stage 4 (15-29), Stage 5 (<15).

What High Estimated GFR Means

High eGFR (above 90) is normal and healthy. Very high values can sometimes be seen in early diabetes or pregnancy.

Common symptoms:

Not typically concerning

What Low Estimated GFR Means

Your kidneys are filtering blood less efficiently than they should. The lower the number, the more advanced the kidney impairment.

Common symptoms:

Often asymptomatic until advanced · Fatigue · Swelling in legs and ankles · Foamy urine · Decreased urine output · Nausea · Itching · Muscle cramps

Why It Matters

When normal:

Gold standard for kidney function assessment

Stages chronic kidney disease

Guides medication dosing

Determines dialysis need

Risks if abnormal:

eGFR 60-89: mild reduction, monitor closely

eGFR 30-59: moderate CKD, active management needed

eGFR 15-29: severe CKD, prepare for dialysis/transplant

eGFR <15: kidney failure

What Can Cause Abnormal Levels?

Diabetes (Diabetic Nephropathy)

45% likely

The #1 cause of kidney disease worldwide. High blood sugar damages tiny kidney blood vessels over years.

High Blood Pressure

40% likely

The #2 cause. Chronic hypertension damages kidney blood vessels and reduces filtration.

Aging

GFR naturally declines ~1 mL/min/year after age 40. Mild reduction in elderly is often normal.

NSAIDs and Nephrotoxic Drugs

Regular ibuprofen, naproxen, or certain antibiotics can damage kidneys over time.

Dehydration

Can temporarily reduce GFR by reducing blood flow to kidneys.

What You Can Do

Control blood pressure: target <130/80

Impact: Single most important kidney protection \u00B7 Timeline: Ongoing

Control blood sugar if diabetic: HbA1c <7%

Impact: Slows diabetic kidney damage \u00B7 Timeline: Ongoing

Stay hydrated: 2-3L water daily

Impact: Supports kidney blood flow \u00B7 Timeline: Ongoing

Limit NSAID use (ibuprofen, naproxen)

Impact: Removes direct kidney toxin \u00B7 Timeline: Immediate

If lifestyle changes aren't enough:

Moderate protein intake: 0.8g per kg if CKD stage 3+

Impact: Reduces kidney workload \u00B7 Timeline: Ongoing

Reduce sodium to <2g/day

Impact: Lowers blood pressure and kidney stress \u00B7 Timeline: 2-4 weeks

Regular exercise

Impact: Improves blood pressure and metabolic health \u00B7 Timeline: 4-8 weeks

Recommended retest: 3-6 months; more frequently if declining

Related Markers

creatinine bun cystatin_c uric_acid albumin urine_protein
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your doctor for diagnosis and treatment.

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